Lab 10 Cell Reproduction and DNA

EIGHT GENES OF MY CHROMOSOME

The number for my Chromosome was 18 

• MIR8078 Also known as hsa-mir-8078

1. MiRNA's are trnascribed by RNA polymerase II as part of capped and polyadenylated primary transpcripts (pri-miRNAs) that can be either protein-coding or non-coding.
2. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs throught imperfect base pairing with the miRNAs and most commonly results in translational inhibition or destablilization of the target mRNA. [provided by RefSeq, Sep 2009]  

•  COLEC12 Also known as CLP1; NSR2; SRCL; SCARA4

1. This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains.
2. A protein that can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. [provided by RefSeq, Sep 2009]   

• YES1 Also known as Yes; c-yes; HsT441; P61-YES

1.  This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene.
2. The encoded protein has tyrosin kinase activity and belongs to the src family of proteins. 
   [provided by RefSeq, Sep 2009]

• TYMS Also known as TS; TMS; HST422

1. Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoythymidylate using 5, 10 methylene-THF as a cofactor. 
2. the enzyme has been of interest as a target for cancer chemotherapeutic agents.  [provided by RefSeq, Sep 2009]  

•  USP14 Also known as TGT

1.  the gene encodes a member of the ubiquitin-specific processing (UBP) family of porteases that is a deubiquitinating enzyme (DUB) with Cys domains.
2. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. [provided by RefSeq, Sep 2009]

•  CETN1 Also known as CEN1; CETN

1.  the protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing.
2. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.  [provided by RefSeq, Sep 2009] 

• LPIN 2 

1.  Mouse studies suggest that this gene functions during normal adipose tissue developement and may play a role in human triglyceride metabolism.
2. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance.  [provided by RefSeq, Sep 2009] 

•  MIR6718 Also known as hsa-mir6718

1.  MicroRNA's (miRNAs) are short non-coding RNAs that are involved in post-transcritional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs.
2. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce a stem-loop precursor miRNA (pre-miRNA), which is further cleaved by a cytoplasmic dicer ribonuclease to generate the mature miRNA.  [provided by RefSeq, Sep 2009]   

Part II 

My opinion of Smart Sparrow as a learning tool:

I enjoyed using Smart Sparrow for the second part of this lab and getting a better perspective on DNA and how a Double Helix is formed.  I found that having instant correction and direction was very helpful and allowed me to make the corrections.  I would not mind using this functions for futher labs.